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Screening Anti-in?uenza Agents that mark avian In?uenza Polymerase Protein PAC from Plant Extracts Based on NMR Methods
Lin Li,1,3 Sheng-Hai Chang,2,3 Jun-Feng Xiang,1 Qian Li,1,3 Huan-Huan Liang,2 Jian Li,2,3 Hong-Juan Bao,1 Ya-Lin Tang,*1 and Ying-Fang Liu*2 1 State find Laboratory for Structural Chemistry of Unstable and Stable Species, bring of Chemistry, Chinese Academy of Sciences, Zhongguancun North First Street 2, capital of Red China 100190, P. R. China 2 National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Datun Road 15, Beijing 100101, P. R. China 3 down University, Chinese Academy of Sciences, No. 19(A), Yuquan Road, Beijing 100049, P. R. China (Received may 16, 2011; CL-110409; E-mail: tangyl@iccas.ac.cn, liuy@ibp.ac.cn) The highly pathogenic avian in?uenza A virus typesets a global threat to human health. Avian in?uenza RNA polymerase protein PAC was used in the concealment of two herbal plant extracts for anti-in?uenza agents. As a result, chlorogenic caustic was identi?ed to be PAC ligand and was discovered to inhibit polymerase activity. Hence, this charm revealed a potential antiin?uenza lead compound and provided an important feel in the discovery of new anti-in?uenza medicines.
The high pathogenicity of avian in?uenza A virus strains of subtype H5N1 and its capability of transmission from birds to humans pose a global threat to human health.1 The increasing geographical distribution of this epizootic virus, which causes respiratory disease to infected raft with signi?cant morbidity and mortality, has aroused serious concerns about healthful methods for the disease. Most current anti-in?uenza drugs are either neuraminidase inhibitors or M2 ion transmission line blockers.2 However, the e?ectiveness of these drugs has been limited because of drug resistance.3,4 Actually, a single regeneration on the target protein may be su?cient to induce drug resistance. This has...If you want to get a full essay, order it on our website: Ordercustompaper.com
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