Natural Drug Extracts For a Nutritive-Tonic Drink,

Natural medicine extracts for a nutritive-tonic drink, promotes the
gun trigger of long-run potentiation in rat hippocampal
dentate gyrus in vivo
Yasuko Sakata, Kumiko Ishige, Tomohiro Ohtakara, Yoshihisa Ito *
Department of Pharmacology, College of Pharmacy, Nihon University, 7-7-1 Narashinodai, Funabashi, Chiba 274-8555, Japan
receive 19 December 2005; accepted 4 April 2006
Available online 11 May 2006
Abstract
We have shown previously that oral brass instrument of a nutritive-tonic drink (NTD) improves scopolamine-induced memory impairment in the
passive turning away task and Morris water-maze in mice and that this action is attri butable to the natural drug extracts, rather than synthetic drugs
such as taurine and caffeine, in the NTD. In pronounce to investigate the mechanism underlying the antiamnesic effectuate of the natural drug extracts, the
effects of the extracts on the induction of long-term potentiation (LTP) was investigated in the dentate gyrus (DG) of normal and scopolaminetreated
rats. Oral administration of natural drug extracts enhanced the induction of population lace amplitude induced by weak tetanic stimulation
(30 pulses at 60 Hz). scopolamine (0.3 mg/kg, i.p.) completely inhibited the induction of LTP induced by both weak and strong tetanic stimulation
(100 pulses at 100 Hz).



Natural drug extracts enhanced partially but significantly the induction of LTP by strong lockjaw, but had a very weak effect
on that induced by weak tetanus. These results suggest that LTP induced by strong tetanus is sensitive to natural drug extracts, and that the
antiamnesic effect of the NTD is at least(prenominal) partly attributable to the LTP-improving effect of the natural drug extracts in the DG.
# 2006 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved.
Keywords: Natural drug extracts; Long-term potentiation; Scopolamine; Hippocampus; Dentate gyrus; Morris water-maze test; Nutritive-tonic drink; tuition and
memory
1. Introduction
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